Multi-omics integration reveals Vha68-3 as a testicular aging-specific factor that coordinates spermatid elongation through mitochondrial metabolic homeostasis
Our findings uncover novel mechanisms by which mitochondrial metabolism regulates spermatid elongation and propose potential therapeutic strategies to combat mitochondrial metabolic disorders in aging testes.
Authors
- Zhiran Li
- Xinda Wang (ORCID: https://orcid.org/0000-0002-2735-2490)
- Ying Zheng (ORCID: https://orcid.org/0000-0003-2723-9022)
- Xiaofang Tan (ORCID: https://orcid.org/0000-0003-0016-6302)
- Bo Zheng (ORCID: https://orcid.org/0000-0002-1496-0753)
- Qiao Chen (ORCID: https://orcid.org/0000-0003-4315-0351)
- Qiuru Huang
- Cong Shen (ORCID: https://orcid.org/0000-0002-9982-176X)
- Hao Chen (ORCID: https://orcid.org/0000-0001-8319-8101)
- Jun Yu (ORCID: https://orcid.org/0000-0003-3109-4102)
- Binbin Yang (ORCID: https://orcid.org/0000-0001-6943-9925)
- Yangbo Fu
- Zhenyu Lin (ORCID: https://orcid.org/0000-0001-7890-6812)
- Yang Xiao-qing (ORCID: https://orcid.org/0000-0003-0880-5324)
- Fei Sun (ORCID: https://orcid.org/0000-0002-0870-8375)
- Lei He (ORCID: https://orcid.org/0000-0001-9642-6804)
- Jiaxin Li (ORCID: https://orcid.org/0000-0002-1681-3271)
- Xia Chen (ORCID: https://orcid.org/0000-0003-2619-1039)
- Chenyu Wang (ORCID: https://orcid.org/0009-0000-2936-6610)
Institutions
- Jiangsu University (CN)
- Nantong University (CN)
- Nantong Maternity and Child Health Hospital (CN)
- Affiliated Hospital of Nantong University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Nanjing Drum Tower Hospital (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Suzhou Municipal Hospital (CN)
- Ningxia Medical University (CN)
- Yangzhou University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s11658-025-00737-3
- Citations
- 4
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 13.98
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Nanjing Medical University
- Qinglan Project of Jiangsu Province of China