Metaresearch on patient-reported outcomes in trial protocols and results publications suggested large outcome reporting bias
Less than half of RCT protocols with planned PROs reported them as specified in corresponding published results, suggesting outcome reporting bias, and PRO reporting quality was often deficient. These limitations complicate informed decision-making between patients and health-care providers, as well as the development of evidence-based clinical practice guidelines.
Authors
- Dominik Mertz (ORCID: https://orcid.org/0000-0003-4337-1613)
- Julian Hirt (ORCID: https://orcid.org/0000-0001-6589-3936)
- Szimonetta Lohner (ORCID: https://orcid.org/0000-0002-6292-4802)
- Selina Epp
- Matthias Briel (ORCID: https://orcid.org/0000-0002-2070-5230)
- Arnav Agarwal (ORCID: https://orcid.org/0000-0002-0931-7851)
- Malena Chiaborelli (ORCID: https://orcid.org/0000-0002-2498-0467)
- Alain Amstutz (ORCID: https://orcid.org/0000-0003-1716-993X)
- Benjamin Speich (ORCID: https://orcid.org/0000-0002-3301-8085)
- Anette Blümle (ORCID: https://orcid.org/0000-0003-2877-1029)
- Ala Taji Heravi (ORCID: https://orcid.org/0000-0003-3752-1611)
- Ramon Saccilotto (ORCID: https://orcid.org/0000-0002-3362-4851)
- Dmitry Gryaznov (ORCID: https://orcid.org/0000-0002-2361-6794)
- L. Hausheer
- Sally Hopewell (ORCID: https://orcid.org/0000-0002-6881-6984)
- Alexandra Griessbach (ORCID: https://orcid.org/0000-0003-3726-1856)
- Erik von Elm (ORCID: https://orcid.org/0000-0002-7412-0406)
- Jason Walter Busse (ORCID: https://orcid.org/0000-0002-0178-8712)
- Belinda von Niederhäusern (ORCID: https://orcid.org/0000-0002-0287-8189)
- Johannes M. Schwenke (ORCID: https://orcid.org/0009-0006-9795-6181)
- Stefan Schandelmaier (ORCID: https://orcid.org/0000-0002-8429-0337)
- Ayodele Odutayo (ORCID: https://orcid.org/0000-0001-8619-5010)
- Manuela Covino
- Christof Schönenberger
- Simon B Egli
- Moshao Amos Makhele
Institutions
- Roche (Switzerland) (CH)
- Swiss Tropical and Public Health Institute (CH)
- University of Freiburg (DE)
- University of Basel (CH)
- Nuffield Orthopaedic Centre (GB)
- University Hospital of Basel (CH)
- University of Oxford (GB)
- Roche Pharma AG (Germany) (DE)
- Centre universitaire de médecine générale et santé publique, Lausanne (CH)
- Impact (CA)
- Tris Pharma (United States) (US)
- University of Pecs (HU)
- McMaster University (CA)
Publication Details
- Journal
- Journal of Clinical Epidemiology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.jclinepi.2025.111822
- Citations
- 2
- Primary Topic
- Clinical practice guidelines implementation
- Type
- article
- Field-Weighted Citation Impact
- 3.76