Iron-catalyzed sequential hydrosilylation
Highly regio-, diastereo- and enantioselective iron-catalyzed sequential hydrosilylation of o-alk-n-enyl-phenyl silanes with alkynes is reported for various 5-, 6-, and 7-membered benzosilacycles in 60-94% yields with up to 95:5 rr, 95:5 dr, and 99% ee. Chiral fully carbon-substituted silicon-stereogenic benzosilacycles could also be obtained via triple hydrosilylation reactions. The unique electronic effect of ligands is observed while adjusting the regioselectivity and enantioselectivity in hydrosilylation reactions. A possible mechanism has been proposed by variable time normalization analysis (VTNA) and H/D exchange experiment.
Authors
- Zhan Lu (ORCID: https://orcid.org/0000-0002-3069-079X)
- Jiajin Zhao
- Liang Deng (ORCID: https://orcid.org/0000-0002-0964-9426)
- Dongyang Wang (ORCID: https://orcid.org/0000-0002-7182-6323)
- Xue Wang (ORCID: https://orcid.org/0009-0007-1593-5318)
Institutions
- Chinese Academy of Sciences (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1038/s41467-025-59364-3
- Citations
- 3
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Natural Science Foundation of China
- Zhejiang University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Zhejiang Province