Safety and efficacy evaluation of intracerebroventricular human neural stem cell transplantation in SOD1 mice as a novel approach for ALS
ICV transplantation of hNSCs emerges as a safe and promising strategy for ALS, demonstrating potential to delay motor decline and reduce spinal cord microgliosis. However, sustained high-dose immunosuppression is crucial for therapeutic efficacy, emphasizing the need for further optimization to overcome translational challenges and achieve durable clinical benefits.
Authors
- Jessica Rosati (ORCID: https://orcid.org/0000-0002-4483-386X)
- Ivan Lombardi (ORCID: https://orcid.org/0000-0001-5682-0823)
- Daniela Celeste Profico (ORCID: https://orcid.org/0000-0001-5721-0410)
- Diego Pastor (ORCID: https://orcid.org/0000-0002-2884-6580)
- Elisa Perciballi (ORCID: https://orcid.org/0000-0001-7186-6547)
- Maurizio Gelati (ORCID: https://orcid.org/0000-0002-4828-9849)
- Salvador Martínez (ORCID: https://orcid.org/0000-0002-3978-9876)
- Daniela Maria Rasà
- Corinne Ferrero (ORCID: https://orcid.org/0000-0002-8974-4879)
- Daniela Ferrari (ORCID: https://orcid.org/0000-0001-7251-9854)
- Alessandro Vercelli (ORCID: https://orcid.org/0000-0002-5909-2128)
- Marina Boido (ORCID: https://orcid.org/0000-0003-1211-1552)
- Angelo L. Vescovi (ORCID: https://orcid.org/0000-0002-1742-4112)
- Rose Mary Carletti (ORCID: https://orcid.org/0000-0002-8429-2527)
- S. Longobardi
- Edvige Vulcano
- Elisa Lazzarino
- Silvia de la Morena
Institutions
- Universitat de Miguel Hernández d'Elx (ES)
- Casa Sollievo della Sofferenza (IT)
- Istituto Universitario di Studi Superiori di Pavia (IT)
- Instituto de Neurociencias (ES)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Neuroscience Institute (IT)
- Link Campus University (IT)
- University of Turin (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12967-025-06529-9
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Dipartimenti di Eccellenza
- Università degli Studi di Milano-Bicocca
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università degli Studi di Torino