Clinical and Experimental Insights into the Role of NETosis in IgA Nephropathy Pathogenesis
Our findings demonstrate that NETosis is upregulated in IgAN and plays a key role in its pathogenesis by promoting inflammatory cytokine release. Inhibition of NETosis improves both clinical and pathological outcomes, highlighting its potential as a therapeutic approach for managing IgAN.
Authors
- X. Li (ORCID: https://orcid.org/0000-0002-9728-098X)
- Xiangyu Qiao
- Chengyu Jiang (ORCID: https://orcid.org/0000-0003-0570-2709)
- Chunyu Jia (ORCID: https://orcid.org/0000-0003-0334-0302)
- Yixin Dong (ORCID: https://orcid.org/0000-0002-5898-9785)
- Gang Chen (ORCID: https://orcid.org/0000-0002-0758-1907)
- Jiahui Wang (ORCID: https://orcid.org/0000-0003-3471-2666)
- Ke Zheng
- Gangan Wang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Kidney Diseases
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1159/000546343
- Citations
- 7
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital