Model-based translation of the PKPD-relationship for linezolid and vancomycin on methicillin-resistant <i>Staphylococcus aureus</i>: from <i>in vitro</i> time–kill experiments to a mouse pneumonia model
A translational workflow allowed us to build a PKPD model with both in vitro and in vivo data that characterized bacterial dynamics following LZD and VAN exposure, showing that this approach can inform the development of antibiotics. We also showcased the first successful use of the standardized mouse pneumonia model for Gram-positive bacteria.
Authors
- Diego Vera‐Yunca (ORCID: https://orcid.org/0000-0003-0821-9456)
- Carina Sofia Silva Matias (ORCID: https://orcid.org/0000-0003-2386-9422)
- Carina Vingsbo Lundberg (ORCID: https://orcid.org/0000-0003-3408-3353)
- Lena E. Friberg (ORCID: https://orcid.org/0000-0002-2979-679X)
Institutions
- Statens Serum Institut (DK)
- Uppsala University (SE)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1093/jac/dkaf140
- Citations
- 4
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- European Federation of Pharmaceutical Industries and Associations
- European Commission
- Innovative Medicines Initiative
- Horizon 2020