Transdiagnostic Neurocognitive Endophenotypes for Schizophrenia, Bipolar I Disorder and a Broad Psychosis/Bipolar I Disorder Phenotype: A Mega-Analysis of Twin and Sibling Data
IQ and SWM tap into transdiagnostic elements of the genetic vulnerabilities to psychosis and BD-I. Our findings add to emergent evidence which spurs cautious optimism that a psychiatric nosology based on aetiology rather than phenotypical classifications may be feasible in the future, enabling biotyping and novel approaches to treatment.
Authors
- Cameron Watson (ORCID: https://orcid.org/0000-0003-2346-4636)
- Fergus Kane (ORCID: https://orcid.org/0000-0003-3703-9067)
- Robin M. Murray (ORCID: https://orcid.org/0000-0003-0829-0519)
- René S. Kahn (ORCID: https://orcid.org/0000-0001-5909-8004)
- Mei‐Hua Hall (ORCID: https://orcid.org/0000-0002-4558-7023)
- Katja Schulze (ORCID: https://orcid.org/0000-0003-3704-5651)
- Cecilie K. Lemvigh (ORCID: https://orcid.org/0000-0002-3647-9709)
- Eugenia Kravariti (ORCID: https://orcid.org/0000-0003-1119-0324)
- Alastair G. Cardno (ORCID: https://orcid.org/0000-0002-6136-5965)
- Marco Picchioni (ORCID: https://orcid.org/0000-0001-6681-147X)
- Neeltje E.M. van Haren (ORCID: https://orcid.org/0000-0002-3090-7653)
- Birte Yding Glenthoj (ORCID: https://orcid.org/0000-0003-3056-7262)
- Sridevi Kalidindi (ORCID: https://orcid.org/0000-0001-8857-5092)
- Frühling Rijsdijk (ORCID: https://orcid.org/0000-0003-4762-2803)
- Bjørn Hylsebeck Ebdrup (ORCID: https://orcid.org/0000-0002-2590-5055)
- Colm McDonald (ORCID: https://orcid.org/0000-0003-1661-5192)
- Timothea Toulopoulou (ORCID: https://orcid.org/0000-0002-9062-8314)
- Argyro G. Fragkaki (ORCID: https://orcid.org/0000-0002-9422-670X)
- Birgitte Fagerlund (ORCID: https://orcid.org/0000-0003-4547-2944)
- Anna Georgiades (ORCID: https://orcid.org/0000-0001-9781-3531)
Institutions
- University of Copenhagen (DK)
- University of Leeds (GB)
- Harvard University (US)
- Bilkent University (TR)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- National and Kapodistrian University of Athens (GR)
- Central and North West London NHS Foundation Trust (GB)
- Mental Health Services (DK)
- McLean Hospital (US)
- Copenhagen University Hospital (DK)
- University Medical Center (US)
- Anton de Kom University of Suriname (SR)
- Resonance Research (United States) (US)
- University College London (GB)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-03-22
- DOI
- https://doi.org/10.1093/schbul/sbaf050
- Citations
- 1
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Psychiatry Research Trust
- National Institute for Health and Care Research
- Lundbeckfonden