Ubiquitin-SUMO tag-team wrestles acute promyelocytic leukemia
In this issue, Jaffray and colleagues (https://doi.org/10.1083/jcb.202407133) detail the molecular machinery required to degrade the oncogene PML in response to arsenic treatment. Different posttranslational modifiers team up: ubiquitin, SUMO1, and -2/3, linked by the SUMO-targeted ubiquitin ligases TOPORS and RNF4.
Authors
- Alfred C.O. Vertegaal (ORCID: https://orcid.org/0000-0002-7989-0493)
Institutions
- Leiden University Medical Center (NL)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1083/jcb.202504010
- Citations
- 1
- Primary Topic
- Retinoids in leukemia and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.81