Diurnal Asymmetric Loading Modulates Cell Phenotype in Intervertebral Disc
Dynamic loading followed by continuous static loading negatively modulates the phenotype of IVD cells in this organ culture model. Comparable to the free swelling treatment after dynamic loading, physical treatment to reduce the stress on the IVD, even temporarily, may help to prevent the acceleration of deformity and degeneration. These results indicate that asymmetric loading followed by static loading may be used to mimic pathological changes of the IVD in spinal deformity.
Authors
- Sibylle Grad (ORCID: https://orcid.org/0000-0001-9552-3653)
- Mauro Alini (ORCID: https://orcid.org/0000-0002-0262-1412)
- Jianbiao Xu
- Zhiyu Zhou (ORCID: https://orcid.org/0000-0002-8101-2083)
- R. Geoff Richards (ORCID: https://orcid.org/0000-0002-7778-2480)
- Zhen Li (ORCID: https://orcid.org/0000-0002-9754-6389)
- Ying Zhang (ORCID: https://orcid.org/0000-0002-5812-372X)
Institutions
- Sun Yat-sen University (CN)
- AO Foundation (CH)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- Shanghai Changzheng Hospital (CN)
- Beijing Hua Xin Hospital (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1002/jsp2.70068
- Citations
- 3
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- AO Foundation
- National Natural Science Foundation of China
- AOSpine