Common Antimicrobial Treatment Considerations for Patients Receiving Comfort-Focused Care: What the Hospice Provider Should Know

Antimicrobials are used in the final few months of life in an attempt to palliate symptoms or treat potentially reversible infections. Antimicrobials cause side effects such as nausea, diarrhea, rash, and allergic reactions. Clinicians should select the narrowest and shortest treatment duration appropriate to the infection. Here, we present common oral antimicrobial agents used at the end of life, highlighting microbial coverage and important prescribing considerations. Providers should be aware of the limitations of antimicrobial treatment for patients at the end of life, particularly those enrolled in hospice, to inform discussions with patients and their families. This will allow tailoring of treatment to the patient's clinical situation and wishes.