Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights

The study highlights the potential of endophytic fungi Aspergillus niger as a promising source of novel antimicrobial and anticancer agents. The identification of 2,2,4,4-tetramethylpentane as the primary bioactive compound, combined with the molecular docking analyses, provides valuable insights into the mechanisms of action and potential therapeutic applications. These findings underscore the importance of exploring endophytic fungi for the development of new drugs to combat antibiotic resistance and cancer.

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Publication Details

Journal
Microbial Cell Factories
Published
2025-05-08
DOI
https://doi.org/10.1186/s12934-025-02710-3
Citations
1
Primary Topic
Phytochemistry and Bioactive Compounds
Type
article
Field-Weighted Citation Impact
0.60

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article

Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights

Mohamed A. Dawoud, Sayed M. S. Abo El-Souad, Mona Soliman, Mahmoud A. A. Ibrahim
1 citations
Microbial Cell Factories
Phytochemistry and Bioactive Compounds
0.60
article

Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights

Mohamed A. Dawoud, Sayed M. S. Abo El-Souad, Mona Soliman, Mahmoud A. A. Ibrahim
article en
1 citations

Abstract

The study highlights the potential of endophytic fungi Aspergillus niger as a promising source of novel antimicrobial and anticancer agents. The identification of 2,2,4,4-tetramethylpentane as the primary bioactive compound, combined with the molecular docking analyses, provides valuable insights into the mechanisms of action and potential therapeutic applications. These findings underscore the importance of exploring endophytic fungi for the development of new drugs to combat antibiotic resistance and cancer.

Microbial Cell FactoriesVol. 24(1)
Cairo University (EG)
Cairo University, Science and Technology Development Fund
Openalex Percentile: Top 34%
Phytochemistry and Bioactive Compounds
0.60
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Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights — Mohamed A. Dawoud, Sayed M. S. Abo El-Souad, et al. · Microbial Cell Factories (2025) | TGRS Research Map | TGRS