Investigating endophytic fungi of Calotropis procera for novel bioactive compounds: molecular docking and bioactivity insights
The study highlights the potential of endophytic fungi Aspergillus niger as a promising source of novel antimicrobial and anticancer agents. The identification of 2,2,4,4-tetramethylpentane as the primary bioactive compound, combined with the molecular docking analyses, provides valuable insights into the mechanisms of action and potential therapeutic applications. These findings underscore the importance of exploring endophytic fungi for the development of new drugs to combat antibiotic resistance and cancer.
Authors
- Mohamed A. Dawoud (ORCID: https://orcid.org/0000-0003-3077-1060)
- Sayed M. S. Abo El-Souad
- Mona Soliman (ORCID: https://orcid.org/0000-0003-0033-7896)
- Mahmoud A. A. Ibrahim (ORCID: https://orcid.org/0000-0003-4819-2040)
Institutions
- Cairo University (EG)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s12934-025-02710-3
- Citations
- 1
- Primary Topic
- Phytochemistry and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.60
Funders
- Cairo University
- Science and Technology Development Fund