An fNIRS-based investigation of cerebral hemodynamic responses during verbal fluency task and n-back task in individuals with mild cognitive impairment
When performing the VFT and 1-back task, our study found that patients with MCI exhibited reduced brain activity levels in the DLPFC and FEF only during the 1-back task. This diminished task-induced brain activity was significantly positively correlated with MoCA scores and was less influenced by mental health and sleep quality. The 1-back task may be a more optimal paradigm for the early detection of MCI compared to the VFT.
Authors
- Yufei Chong (ORCID: https://orcid.org/0009-0005-0513-0570)
- Peiwen Zhang (ORCID: https://orcid.org/0000-0001-5923-474X)
- Zhen Cheng (ORCID: https://orcid.org/0000-0003-3056-5611)
- Zhengliang Li (ORCID: https://orcid.org/0000-0002-3470-372X)
- Jingyi Gong (ORCID: https://orcid.org/0000-0001-7848-1084)
- Wenguang Xia (ORCID: https://orcid.org/0000-0003-2508-4741)
- Lirong Xia (ORCID: https://orcid.org/0000-0002-9800-6691)
- Chanjuan Zheng
- Qingqing Wu
- Can Duan
- Jialing Sun
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei Provincial Hospital of Traditional Chinese Medicine (CN)
- Integrated Chinese Medicine (China) (HK)
- Hubei 672 Orthopedics Hospital of Traditional Chinese Medicine and Western Medicine (CN)
- Hubei Provincial Hospital of Integrative Medicine (CN)
- International Neuromodulation Society (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fneur.2025.1571964
- Citations
- 7
- Primary Topic
- Optical Imaging and Spectroscopy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 9.52