Investigating the shared genetic architecture between obesity and depression: a large-scale genomewide cross-trait analysis
This study demonstrates the genetic causal relationship and common risk SNPs, genes, proteins, and pathways between obesity and depression. These findings contribute to a deeper understanding of their pathogenesis and the identification of potential therapeutic targets.
Authors
- Tiance Wang
- Kexiang Liu (ORCID: https://orcid.org/0000-0002-9350-4499)
- Ki‐Tae Ha (ORCID: https://orcid.org/0000-0001-6283-0171)
- Minkyoung Cho (ORCID: https://orcid.org/0000-0002-1776-7254)
- Yale Su
- Dan Li (ORCID: https://orcid.org/0000-0002-1349-5714)
- Man Li (ORCID: https://orcid.org/0000-0002-3839-0281)
- Hui Wang (ORCID: https://orcid.org/0000-0002-0272-0015)
- Lei Yuan (ORCID: https://orcid.org/0000-0002-9908-2266)
- Mi-Ju Park (ORCID: https://orcid.org/0000-0003-0442-4604)
- Hulin Piao
- Dongdong Zheng (ORCID: https://orcid.org/0000-0001-6189-9046)
- Zhicheng Zhu (ORCID: https://orcid.org/0000-0001-8166-5597)
- Long Yuan (ORCID: https://orcid.org/0000-0002-3450-0316)
- Jiangqi Zhao
- Yong Wang (ORCID: https://orcid.org/0000-0003-0695-5273)
Institutions
- Gyeongsang National University (KR)
- Second Affiliated Hospital of Jilin University (CN)
- First Affiliated Hospital of Henan University (CN)
- Pusan National University (KR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fendo.2025.1578944
- Citations
- 3
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Natural Science Foundation of Jilin Province
- People's Government of Jilin Province