Identification of candidate genes harboring pathogenic variants in congenital heart disease and laterality defects in Chinese population
This research identified two novel candidate genes (<i>DNAH2</i>, and <i>FLNA</i>) for CHD/LD in the Chinese population, with <i>DNAH2</i> ciliary genes being the most frequently occurring among all candidate genes. The results offer critical insights into the genetic basis of CHD/LD in the Chinese population, which may have implications for genetic counseling and prenatal prevention.
Authors
- Weili Yan (ORCID: https://orcid.org/0000-0002-7633-7449)
- Quannan Zhuang
- Maoxiang Qian (ORCID: https://orcid.org/0000-0003-2889-546X)
- Feizhen Wu
- Chaozhong Tan (ORCID: https://orcid.org/0000-0003-4683-9349)
- Han Gao (ORCID: https://orcid.org/0000-0003-1633-6652)
- Wei Sheng (ORCID: https://orcid.org/0000-0001-7473-0864)
- Jinxin Wang (ORCID: https://orcid.org/0000-0002-2906-0504)
- Wei‐Cheng Chen (ORCID: https://orcid.org/0000-0001-6578-000X)
- Zhiyu Feng
- Yuquan Lu (ORCID: https://orcid.org/0000-0002-1486-0015)
- Guoying Huang (ORCID: https://orcid.org/0000-0001-9887-8978)
- Xianghui Huang
- Yuan Gao (ORCID: https://orcid.org/0009-0009-4598-2486)
- Shaojie Min
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Children's Hospital of Fudan University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fgene.2025.1582718
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China