Metformin improves intestinal ischemia-reperfusion injury by reducing the formation of mitochondrial associated endoplasmic reticulum membranes (MAMs) and inhibiting ferroptosis in intestinal cells
In conclusion, this study suggests that metformin exerts beneficial effects on intestinal I/R injury by suppressing MAM formation and ferroptosis, thereby highlighting its potential as a therapeutic agent for this challenging clinical condition.
Authors
- Lifei Tian
- Xiao-Long Zhang (ORCID: https://orcid.org/0000-0002-8071-7727)
- Zeyu Li (ORCID: https://orcid.org/0000-0001-9568-3315)
- Xu Zhao
- Ruiting Liu (ORCID: https://orcid.org/0000-0002-1028-3214)
- Likun Yan (ORCID: https://orcid.org/0000-0003-3833-3583)
Institutions
- Shanxi Medical University (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fphar.2025.1581085
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87