Role of lncRNA Xist-miR-124-CCL2 axis in HIV Tat-mediated microglial activation and neuroinflammation
Our findings identify a novel regulatory axis whereby HIV Tat-induced upregulation of lncRNA Xist sponges miR-124, leading to CCL2 overexpression and microglial activation. Targeting the lncRNA Xist-miR-124-CCL2 pathway may represent a promising therapeutic strategy to mitigate neuroinflammation associated with NeuroHIV.
Authors
- Palsamy Periyasamy (ORCID: https://orcid.org/0000-0002-0386-5611)
- Shilpa J. Buch (ORCID: https://orcid.org/0000-0002-3103-6685)
- Seema Singh (ORCID: https://orcid.org/0000-0001-9382-0603)
- Abiola Oladapo (ORCID: https://orcid.org/0000-0003-2225-1129)
- Muthukumar Kannan (ORCID: https://orcid.org/0000-0002-6545-229X)
Institutions
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1558842
- Citations
- 2
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- National Institutes of Health
- National Institute of Mental Health