Identification of SCAMP2 as a regulator of NOTCH signaling in cisplatin resistance through a novel prognostic model for bladder cancer
These findings underscore the potential of CSRGs, particularly SCAMP2, as critical biomarkers for bladder cancer prognosis. The identification of SCAMP2 as a regulator of NOTCH signaling in cisplatin resistance offers new insights into the molecular mechanisms of chemotherapy resistance and suggests potential therapeutic targets for overcoming drug resistance. Our model could guide personalized treatment strategies and improve bladder cancer patient outcomes.
Authors
- Long Shi (ORCID: https://orcid.org/0000-0002-4909-4349)
- Shaoqi Zhang (ORCID: https://orcid.org/0000-0002-5370-0487)
- Longjun Cai
- Furong Ji
- Jin Wang (ORCID: https://orcid.org/0000-0001-5178-7606)
- Jianjun Zhang (ORCID: https://orcid.org/0000-0002-8329-2357)
- Xiangyu Wang (ORCID: https://orcid.org/0000-0003-2250-8676)
- Zhiyong Chen (ORCID: https://orcid.org/0000-0003-2309-775X)
- Chao Liu (ORCID: https://orcid.org/0000-0002-7411-7821)
- Fangfang Zheng
Institutions
- Xuzhou Medical College (CN)
- Soochow University (CN)
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1573412
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00