Multi-omics analysis and experiments uncover the link between cancer intrinsic drivers, stemness, and immunotherapy in ovarian cancer with validation in a pan-cancer census
Our study has uncovered a robust correlation between variations in cancer intrinsic drivers and stemness, as well as resistance to immunotherapy. This finding provides valuable insights for potential strategies to overcome immune resistance by targeting genes associated with stemness.
Authors
- Xiangqian Gao
- Jie Mei (ORCID: https://orcid.org/0000-0001-7799-8129)
- Lingwen Kong (ORCID: https://orcid.org/0000-0002-4663-555X)
- Ningxiao Jiang
- Lei Han (ORCID: https://orcid.org/0000-0002-5156-4258)
- Yingjiang Xu (ORCID: https://orcid.org/0000-0001-6492-9132)
- Gaofeng Qin (ORCID: https://orcid.org/0000-0001-6482-4242)
- Shinan Zhang
- Weiwei Chen (ORCID: https://orcid.org/0000-0003-2289-3578)
- Yilin Li (ORCID: https://orcid.org/0000-0001-9408-6738)
- Fei Wang (ORCID: https://orcid.org/0000-0002-5670-1944)
- Cen Chen (ORCID: https://orcid.org/0000-0002-4188-4362)
- Li Yan (ORCID: https://orcid.org/0000-0002-2218-8644)
- Xiaoyu Ji (ORCID: https://orcid.org/0000-0003-2524-8363)
- Qiang Tang
- Yanlin Wang (ORCID: https://orcid.org/0009-0009-0821-9318)
Institutions
- Binzhou Medical University (CN)
- University of Electronic Science and Technology of China (CN)
- Shandong University of Aeronautics (CN)
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1549656
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province