Protective effects of AER-271 in acute-phase radiation-induced brain injury in rats: reduction of brain edema, inflammation, apoptosis and maintenance of blood-brain barrier integrity
AQP4 is involved in regulating the subsequent inflammatory response, BBB injury and apoptosis by mediating the development of cerebral edema during the acute phase of RIBI. AER-271 is expected to be a promising therapeutic candidate for the treatment of RIBI by inhibiting the expression of AQP4.
Authors
- Yu‐Suo Tong
- Yaozu Xiong
- Yifei Wang (ORCID: https://orcid.org/0000-0002-9620-4897)
- Mingyue Li (ORCID: https://orcid.org/0000-0003-4207-8917)
- Xiaoting Xu (ORCID: https://orcid.org/0000-0001-7357-7431)
- Changhua Yu
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fphar.2025.1534729
- Citations
- 2
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.68