Helicobacter pylori induced miR-362-5p upregulation drives gastric cancer progression and links hepatocellular carcinoma through an exosome-dependent pathway
<i>H. pylori</i> infection upregulates miR-362-5p, facilitating GC progression via TLE4 targeting. Exosome-mediated transfer amplifies its effects, contributing to liver damage and potentially facilitating HCC.
Authors
- Xiaofei Ji (ORCID: https://orcid.org/0000-0002-0461-1007)
- Shuqing Chen (ORCID: https://orcid.org/0000-0002-0792-3735)
- Jianhui Zhang (ORCID: https://orcid.org/0009-0007-0079-2836)
- Yinuo Zhang (ORCID: https://orcid.org/0000-0001-8956-7334)
- Juan Zhang (ORCID: https://orcid.org/0000-0001-6241-7176)
- Xinying Cao
- Huilin Zhao (ORCID: https://orcid.org/0000-0003-3023-5292)
- Shuzhen Liu (ORCID: https://orcid.org/0000-0002-0602-3217)
- Chao Gao (ORCID: https://orcid.org/0000-0003-1173-5881)
- M.U. Feng
- Zekun Sun
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fcimb.2025.1582131
- Citations
- 4
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.75
Funders
- Natural Science Foundation of Shandong Province
- Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China