Serum cystatin C as a potential biomarker for generalized acetylcholine receptor antibody-positive myasthenia gravis
Serum Cys-C levels were significantly elevated in AChR-Ab positive gMG patients and correlated with disease severity and Th1/Th2 ratio, suggesting its potential as an efficient biomarker for predicting the clinical severity of MG. Future prospective cohort studies with a large sample size are expected to validate these findings.
Authors
- Lei Jin (ORCID: https://orcid.org/0000-0002-9052-4590)
- Xiao Huan (ORCID: https://orcid.org/0000-0002-6122-4804)
- Huahua Zhong (ORCID: https://orcid.org/0000-0002-7852-3982)
- Ran Chen (ORCID: https://orcid.org/0009-0004-0722-4039)
- Chongbo Zhao (ORCID: https://orcid.org/0000-0001-9481-1418)
- Dingxian He (ORCID: https://orcid.org/0009-0005-9955-7179)
- Shanfeng Zhu (ORCID: https://orcid.org/0000-0002-6067-5312)
- Jianying Xi (ORCID: https://orcid.org/0000-0003-1028-3801)
- Sushan Luo (ORCID: https://orcid.org/0000-0002-9033-7568)
- Rui Zhao (ORCID: https://orcid.org/0000-0002-5971-1638)
- Chong Yan (ORCID: https://orcid.org/0009-0009-1451-3388)
- Jie Song (ORCID: https://orcid.org/0000-0002-3267-8348)
- Zongtai Wu (ORCID: https://orcid.org/0000-0002-8609-1016)
Institutions
- University of Cambridge (GB)
- Fudan University (CN)
- Huashan Hospital (CN)
- Shanghai Center for Brain Science and Brain-Inspired Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1578359
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Shanghai Hospital Development Center