The safety of combining Endostar with concurrent chemoradiotherapy for the treatment of locally advanced cervical cancer and the evaluation of its anti-angiogenic effects via transrectal contrast-enhanced ultrasound
The combination of Endostar with CCRT for locally advanced cervical cancer (LACC) demonstrated favorable safety and tolerability. Transrectal contrast-enhanced ultrasound (CEUS) effectively assessed tumor vascular normalization induced by Endostar during CCRT. Specifically, Endostar significantly reduced VM rates and shortened MTT, suggesting its potential to normalize tumor vasculature.
Authors
- Chao‐Hui Zheng (ORCID: https://orcid.org/0000-0003-0157-5167)
- Xiaobi Tang
- Fang Wu (ORCID: https://orcid.org/0009-0002-7749-1525)
- Jinting Que
- Li Jiang (ORCID: https://orcid.org/0000-0002-0515-2594)
- Shanshan Ma (ORCID: https://orcid.org/0000-0002-3004-9468)
- Zhou Li (ORCID: https://orcid.org/0000-0002-9401-1012)
- Yong Zhang (ORCID: https://orcid.org/0000-0001-5333-7684)
- Qiufeng Huang
- Z. Lu
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Tumor Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fonc.2025.1514425
- Citations
- 2
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.11