Identification of common hub genes and construction of immune regulatory networks in aplastic anemia, myelodysplastic syndromes, and acute myeloid leukemia
POLG and MAP2K7 demonstrate crucial roles in the progression from AA to MDS and, ultimately, to AML. These genes regulate more than 20 immune regulatory pathways through MIF-mediated communication, thereby influencing disease progression.
Authors
- Long Sui (ORCID: https://orcid.org/0000-0003-0921-4366)
- Wenzhe Yang (ORCID: https://orcid.org/0009-0008-4085-0997)
- Mingliang Shan
- Ping Sun (ORCID: https://orcid.org/0000-0003-4607-0592)
- Shiguo Liu (ORCID: https://orcid.org/0000-0001-6474-4082)
- Li Xu
- Xiumei Zhuo
Institutions
- Qingdao University (CN)
- Weifang Medical University (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Affiliated Hospital of Qingdao University (CN)
- Gaozhou People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1547289
- Citations
- 2
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 3.54