Evaluation of humoral and cellular immune responses in healthcare workers with varying levels of SARS-CoV-2 exposure: effects of CoronaVac vaccination followed by heterologous booster
The CoronaVac elicited an antigen-specific cellular immune response, characterized by enhancing the production of key cytokines such as IFN-γ and IL-2, with high levels of anti-S IgG. Furthermore, the administration of heterologous boosters significantly enhanced these immune responses, demonstrating induced-specific immunological response. These findings underscore the importance of primary vaccination and boosters in inducing immune protection against COVID-19, potentially informing future vaccination policies and approaches.
Authors
- Marcelo Ribeiro‐Alves (ORCID: https://orcid.org/0000-0002-8663-3364)
- Wânia Ferraz Pereira Manfro
- Vinícius da Cunha Lisboa
- Luís Cristóvão Pôrto (ORCID: https://orcid.org/0000-0003-1499-1821)
- Jeane de Souza Nogueira (ORCID: https://orcid.org/0000-0002-4952-2278)
- Silvia A. G. Da-Silva (ORCID: https://orcid.org/0000-0003-1600-1238)
- Luciana Silva Rodrigues (ORCID: https://orcid.org/0000-0003-0743-1009)
- Sofia Ferreira Azevedo (ORCID: https://orcid.org/0000-0002-1786-7925)
- Andréia Carolinne de Souza Brito
- Roberto Stefan de Almeida Ribeiro (ORCID: https://orcid.org/0000-0003-1245-0386)
- Patrícia Maria Lourenço Dutra (ORCID: https://orcid.org/0000-0002-2494-6912)
- Leda dos Reis Castilho
- Shayane Martins Rodrigues Gomes (ORCID: https://orcid.org/0000-0002-4836-5725)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1576430
- Citations
- 1
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
- Fundação Oswaldo Cruz
- Universidade do Estado do Rio de Janeiro