Ten years after introduction of NADC30-like strain in China: a novel chimeric porcine reproductive and respiratory syndrome vaccine candidate
Chimeric virus RvBJ-4-(ORF2-6)SX demonstrates a favorable balance between safety and efficacy, with limited pathogenicity and providing faster viremia clearance as well as reduced lung lesions in vaccinated/challenged pigs. A novel strategy for providing safe and effective immunological protection against NADC30-like strains has been introduced, with the potential for implementation in the field.
Authors
- Yongning Zhang (ORCID: https://orcid.org/0000-0002-0134-2761)
- Xinyu Fang (ORCID: https://orcid.org/0000-0002-3503-7765)
- Weixin Wu (ORCID: https://orcid.org/0000-0002-0734-3247)
- Xinna Ge (ORCID: https://orcid.org/0000-0002-5368-9687)
- Hanchun Yang (ORCID: https://orcid.org/0000-0003-3359-3925)
- Jun Han (ORCID: https://orcid.org/0000-0002-7104-7223)
- Yiyao Jiang (ORCID: https://orcid.org/0000-0002-7142-0390)
- Lei Zhou (ORCID: https://orcid.org/0000-0002-8837-3965)
- Xin Guo (ORCID: https://orcid.org/0000-0001-6789-3139)
- Peng Gao (ORCID: https://orcid.org/0000-0002-8981-4988)
- Qiongqiong Zhou
- Jiameng Hu
Institutions
- Ministry of Agriculture and Rural Affairs (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1585197
- Citations
- 1
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.19