Single-cell RNA sequencing reveals adrb1 as a sympathetic nerve-regulated immune checkpoint driving T cell exhaustion and impacting immunotherapy in esophageal squamous cell carcinoma
ADRB1 expression increases after neoadjuvant therapy in ESCC and correlates with poor prognosis. Our findings suggest ADRB1 as a potential prognostic biomarker and therapeutic target for post-neoadjuvant immunotherapy.
Authors
- Ying Liu (ORCID: https://orcid.org/0000-0002-7205-9365)
- Qun Li (ORCID: https://orcid.org/0000-0002-5501-8262)
- Ke Li (ORCID: https://orcid.org/0000-0002-0369-2749)
- Cheng Zhang
- Yulin Ren
- Shuning Xu
Institutions
- Zhengzhou University (CN)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1520766
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18