Exploring the role of cell cycle regulation in human mature adipocyte dedifferentiation
Both human adipose tissue depots undergo dedifferentiation <i>in vitro</i>, but visceral adipose tissue DFAT cells retain more lipids than subcutaneous-derived DFAT cells. Liposecretion is characterized by the rapid ejection of a membrane-wrapped lipid droplet. This phenomenon is dependent on CDK1 and likely relies on the presence of integrin-mediated cellular adherence.
Authors
- Marie‐Ève Tremblay (ORCID: https://orcid.org/0000-0003-2863-9626)
- Nathalie Vernoux (ORCID: https://orcid.org/0000-0001-9263-6847)
- Stéfane Lebel (ORCID: https://orcid.org/0000-0003-0917-3752)
- Émilie Bernier (ORCID: https://orcid.org/0009-0000-5668-3435)
- Giada Ostinelli
- André Tchernof (ORCID: https://orcid.org/0000-0002-2587-1000)
- Simon Marceau (ORCID: https://orcid.org/0000-0001-7299-6597)
- Marie‐Frédérique Gauthier
- Tristan Dubé
Institutions
- University of Victoria (CA)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Université Laval (CA)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fcell.2025.1547836
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Natural Sciences and Engineering Research Council of Canada