Waldenström's Macroglobulinemia with Biclonal Gammopathy: A Case Report

Waldenström macroglobulinemia (WM) is a rare, indolent lymphoproliferative disorder characterized by the accumulation of abnormal lymphoplasmacytic cells in the bone marrow. These cells produce excessive amounts of monoclonal immunoglobulin M (IgM) protein, leading to symptoms such as fatigue, bleeding problems, and increased susceptibility to infections. In recent years, biclonal gammopathy, defined as the presence of two distinct monoclonal proteins in a patient’s blood or urine, has been increasingly recognized in some WM patients. For instance, Nakazaki et al., (2010) reported cases of WM with coexisting non-IgM gammopathy, specifically IgG.