Hypolipidemic Action of Leaf Extracts of Raphanus sativus var. Longipinnatus in High Fat Diet Induced Rats

This study aims to investigate the hypolipidemic effects of an aqueous extract from the leaves of Raphanus sativus var. longipinnatus using rat models. Hyperlipidaemia, a condition caused by a high-fat diet, was produced in Wistar albino rats through the continuous administration of such food. During this period, weight growth and changes to the serum lipid profile were observed. It specifically indicated a reduction in high-density lipoprotein levels and an increase in total cholesterol (185±0.96), triglycerides (281±1.2), low-density lipoprotein (123±2.0), and very low-density lipoprotein (57±1.4). Atorvastatin administered at a dosage of 10 mg/kg served as the reference medication for the standardisation process. Following a 14-day testing period, rats administered 300 mg/kg of leaf extract exhibited a significant alteration in their weight. A significant increase (P<0.001) was observed in total cholesterol, triglycerides, low-density lipoprotein, and very low-density lipoprotein after the administration of the 300 mg/kg dosage. The quantity of high-density lipoprotein significantly increased (P<0.001) with the 200 mg/kg dosage. Microscopic examination of the liver elucidates the alterations that transpire in hepatic cells throughout the course of treatment. The leaf extract exhibited a notable reduction in oxidative stress markers, along with decreased SGOT and SGPT levels. Comprehensive studies demonstrate that the use of the leaf extract resulted in weight gain and an improved lipid profile in the blood stream.