A Longitudinal Study of the Bidirectional Temporal Dynamics Between Body Mass Index and Biological Aging
Higher BMI predicted a steeper increase in FI, substantiating the hypothesis that obesity accelerates biological aging. Higher biological aging, measured as FI and FAI, drove a steeper BMI decline in late life, signalling that late-life weight loss may result from accelerated aging. Higher BMI may accelerate aspects of the aging process, and the aging process, in turn, accelerates late-life BMI decline, necessitating an integrated approach to manage both obesity and unintentional weight loss among older adults.
Authors
- Alexander Ploner (ORCID: https://orcid.org/0000-0002-5042-8326)
- Nancy L. Pedersen (ORCID: https://orcid.org/0000-0001-8057-3543)
- Anna K. Dahl Aslan (ORCID: https://orcid.org/0000-0002-6305-8993)
- Deborah Finkel (ORCID: https://orcid.org/0000-0003-2346-2470)
- Chandra A. Reynolds (ORCID: https://orcid.org/0000-0001-6502-7173)
- Peggy Ler (ORCID: https://orcid.org/0000-0002-4845-1180)
- Juulia Jylhävä (ORCID: https://orcid.org/0000-0003-0250-4491)
- Jonathan K. L. Mak (ORCID: https://orcid.org/0000-0003-4454-8580)
- Ida Karlsson (ORCID: https://orcid.org/0000-0003-3605-7829)
Institutions
- University of Southern California (US)
- Tampere University (FI)
- Chinese University of Hong Kong (HK)
- University of Colorado Boulder (US)
- University of Skövde (SE)
- Karolinska Institutet (SE)
- Tampere University (FI)
- University of Hong Kong (HK)
- Jönköping University (SE)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1002/jcsm.13824
- Citations
- 2
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- John D. and Catherine T. MacArthur Foundation
- Vårdalstiftelsen
- Karolinska Institutet
- Vetenskapsrådet
- Forskningsrådet om Hälsa, Arbetsliv och Välfärd
- Erik och Edith Fernströms Stiftelse för Medicinsk Forskning
- National Institutes of Health
- National Institute on Aging