The Evidence Based Wound Healing Activity of Herbal Plant Populus deltoides on Albino Wistar Rats

The purpose of the study was to analyse the potential of Populus deltoides leaves in Wistar rats, prepared three gel formulations: 2% (Gel A), 4% (Gel B) and 6% (Gel C) with ethanolic extract of Populus deltoides. The 5 groups of 6 wistar albino rats respectively were separated into; group 1 considered negative control (placebo), group 2 considered standard (2% Povidone iodine), group 3 treated with Gel A (2%), group 4 treated with Gel B (4%) and group 5 treated with Gel C (6%) as test groups. Each therapy was administered daily one time. The impact of wound healing was evaluated using the percent of wound contraction, histology test and tensile strength in both the excision and incision models. In each of the investigated models, Gel B and Gel C strongly enhanced wound healing activity. Gel C gave 100% positive result and gel B gave 94% positive result, whereas the negative control group gave 74% result. The result of gel C was highly significant (p≤0.001) when compared to the negative control group. It was figured out that the formulated Gel C (6% ethanolic extract of Populus deltoides) provided significant effect as compared to control in wound healing potential in excision & incision wounds.