Extract of Psidium guajava Attenuates Haloperidol Induced Parkinsonismlike Symptoms in Wister albino rats

Neurodegeneration, or the degeneration of neurons, is one of the main causes of neurological diseases. Because adenosine A2a receptor antagonists have neuroprotective properties, they were studied in a haloperidol animal model of Parkinson's disease. This study was designed to evaluate the Anti-parkinsonism activity of Psidium guajava leaves ethanolic extract in experimental animals. The ethanolic extract of Psidium guajava leaves was screened for anti-parkinsonism activity against haloperidol induced Parkinsonism models. The various relevant behavioural activity and biochemical parameters like Locomotor activity, Catalepsy, Hang test and SOD, MDA, GSH. respectively were estimated. The evaluation of anti-parkinsonism potential of extract evoked a significant dose dependent effect in haloperidol induced models as well as on biochemical parameters such as, SOD, GSH, MDA levels was observed by comparing with control group. The ethanolic extract of Psidium guajava leaves treated groups showed significant protection by reversing the levels of SOD, MDA, GSH as compared with control group. Histopathology observation also confirmed the neuroprotective property of Psidium guajava leaves. Ethanolic extract of Psidium guajava leaves possess significant anti-parkinsonism activity in haloperidol models. This observed activity of the plant attributed to the phytochemicals present in the extract.