VALPROIC ACID LOADED NIOSOMAL IN SITU GEL: A NOVEL APPROACH FOR EPILEPSY TREATMENT

Valproic acid is an antiepileptic medication that is primarily used to treat epilepsy and bipolar disorder. This investigation was designed with three objectives in mind. First, improve the solubility and bioavailability of the BCS class II medicine valproic acid; second, make it easy to give the drug to an epileptic patient during an episode; and third, lower the dosage for long-term treatment. Niosomal formulations were optimized using various Tween and Span range ratios. The formulations were made using the ether injection method. The formulation's morphological characterization, entrapment efficiency, viscosity, and particle size were evaluated. Valproic acid niosomes prepared with Tween 20 and Span 80 have been found to be capable of capturing large quantities of medicine. After that, niosome was added to bioadhesive polymer and evaluated for pH, viscosity, spreadability, drug content, in-vitro drug release, and short-term stability. Adequate in vitro drug release from the gel on the nasal mucosa of goat was demonstrated by vesicles trapped in an in situ nasal gel formulation. In the histological analysis, no surfactant impact was seen, and neither formulation harmed the nasal tissue. We can therefore draw the conclusion that niosomal in situ nasal gel therapy is a viable treatment option for the antiepileptic medication valproic acid.