Effects of Tirzepatide on Patients With Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease: A Retrospective Cohort Study

This study suggested the efficacy of switching from GLP-1RAs to tirzepatide among Japanese patients with type 2 diabetes and MASLD. Predictors of weight loss and fatty liver index reduction after switching to tirzepatide were identified. Additionally, we found that the therapeutic effect of tirzepatide can be expected even in patients who were using semaglutide before the switch.