Creation of Genetically Modified Adipocytes for Tissue Engineering: Creatine Kinase B Overexpression Leads to Stimulated Glucose Uptake and Mitochondrial Potential Growth, but Lowered Lipid Synthesis
In this study, we have shown that CKB overexpression in mature adipocytes allows us to obtain adipocytes with high glucose uptake, potency of ATP synthesis, and suppressed lipogenesis. These genetically modified cells may potentially exhibit a favorable metabolic effect in the context of excessive nutrient utilization.
Authors
- Yelena Parfyonova (ORCID: https://orcid.org/0000-0002-0969-5780)
- Margarita Agareva (ORCID: https://orcid.org/0000-0002-9603-9780)
- И. Б. Белоглазова (ORCID: https://orcid.org/0000-0002-2345-3681)
- Iurii Stafeev (ORCID: https://orcid.org/0000-0003-3514-3936)
- Svetlana Michurina (ORCID: https://orcid.org/0000-0001-6027-2217)
- Н. В. Алексеева (ORCID: https://orcid.org/0000-0001-8972-3376)
Institutions
- Lomonosov Moscow State University (RU)
- National Medical Research Center of Cardiology (RU)
Publication Details
- Journal
- Life
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3390/life15050753
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Russian Science Foundation
- Lomonosov Moscow State University