In Vivo Safety Assessment of AZT-derived OrganochalcogenCompounds with Promising Antiviral Effects against SARS-Cov-2
We hypothesize that Se and Te atom insertion may alter pharmacological properties by modulating DAF-16, GST-4, and ROS-related pathways. in silico data suggest these derivatives are promising for antiviral activity, targeting nucleotide metabolism and DNA replication while also potentially modulating the anti-inflammatory response, an appealing feature for COVID-19 treatment.
Authors
- D. N. Nunes
- Rafael Santos da Silva
- Oscar E. D. Rodrigues (ORCID: https://orcid.org/0000-0003-4382-1637)
- Daniela Teixeira Rodrigues
- Custer C. Deocaris (ORCID: https://orcid.org/0000-0003-3530-1228)
- Daiana Silva Ávila (ORCID: https://orcid.org/0000-0002-8673-1909)
- Joana Oliveira (ORCID: https://orcid.org/0000-0002-9996-1463)
- João Batista Teixeira da Rocha
- Eugênia Carla Kuhn
- Natália da Silva Silva Jardim
Institutions
- Philippine Medical Association (PH)
- Universidade Federal de Santa Maria (BR)
- Philippine Heart Center (PH)
- Universidade Federal do Pampa (BR)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-05-08
- DOI
- https://doi.org/10.2174/0109298673367163250417065816
- Primary Topic
- Metalloenzymes and iron-sulfur proteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00