Metabolomics and Network Pharmacology Analyses Reveal the Mechanism of Moxibustion in Knee Osteoarthritis
The mechanism of moxibustion in knee osteoarthritis may involve alanine, aspartate, and glutamate metabolism, cysteine and methionine metabolism, arginine and proline metabolism, amino tRNA biosynthesis, and D-glutamine and D-glutamate metabolism signaling pathways with MAPK-3, AKT-1, RELA, MAPK-8, and MAPK-14 as core targets. More precise mechanisms need to be verified by further systematic molecular biology experiments.
Authors
- Yaqiong Su (ORCID: https://orcid.org/0000-0001-5581-5352)
- Chunliu Wang (ORCID: https://orcid.org/0000-0002-2345-4035)
- Ye Li (ORCID: https://orcid.org/0000-0001-5537-4569)
- Yaning Zhang (ORCID: https://orcid.org/0000-0001-5763-298X)
- Zhongdong Qiao (ORCID: https://orcid.org/0000-0002-2261-4586)
- Jing Li (ORCID: https://orcid.org/0000-0001-9392-6600)
- Hong Zhang (ORCID: https://orcid.org/0000-0003-1682-8171)
- Minfeng Fang (ORCID: https://orcid.org/0000-0003-0839-0595)
- Na Zheng
- Weipeng Zhao (ORCID: https://orcid.org/0000-0002-7909-9490)
- Yun Yang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Northwest University (CN)
- Jiangsu Provincial Academy of Traditional Chinese Medicine (CN)
- Microbiology Institute of Shaanxi (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-05-07
- DOI
- https://doi.org/10.2174/0113862073365403250423070858
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67