Spinosin Suppresses RANKL-induced Osteoclastogenesis andAlleviates LPS-induced Cranial Osteolysis: A Study based onNetwork Pharmacology and Experimental Validation
Spinosin can inhibit EGFR-mediated Akt phosphorylation, which in turn negatively affects downstream Nfatc1-mediated osteoclast-associated gene expression and subsequent osteoclast formation and functionality, mitigating the LPS-induced osteolysis. Our study proves that spinosin holds the promise of being an innovative drug to prevent inflammatory osteolysis.
Authors
- Shui Sun (ORCID: https://orcid.org/0000-0002-9744-1595)
- Lei Tian (ORCID: https://orcid.org/0000-0002-1929-3953)
- Jianxun Ge
- Yang Su (ORCID: https://orcid.org/0009-0004-2590-1654)
- Meng Qi (ORCID: https://orcid.org/0000-0003-3609-2560)
- Shankun Dong
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-05-05
- DOI
- https://doi.org/10.2174/0109298673371731250415115235
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00