Nutraceutical Synergy: Unraveling the Protective Effects of Methyl Gallate andChia Seed Oil in Doxorubicin-induced Hepatic Injury and Bax/Bcl2 Imbalance
Methyl gallate and chia seed oil, individually and in combination, demonstrated significant hepatoprotective effects against doxorubicin-induced hepatotoxicity, with the combination showing the greatest efficacy. These nutraceuticals hold promise as adjunct therapies to reduce doxorubicin-induced liver injury.
Authors
- Shakta Mani Satyam (ORCID: https://orcid.org/0000-0001-5761-2073)
- Akheruz Zaman Ahmed (ORCID: https://orcid.org/0000-0003-0286-6716)
- Kosuri Kalyan Chakravarthi (ORCID: https://orcid.org/0000-0001-7187-8687)
- P. Sainath
- Manfredi Rizzo (ORCID: https://orcid.org/0000-0002-9549-8504)
- Mohamed El‐Tanani (ORCID: https://orcid.org/0000-0002-4735-5445)
- Rashmi Kumari (ORCID: https://orcid.org/0000-0001-5433-8291)
- Prakashchandra Shetty (ORCID: https://orcid.org/0000-0001-9277-4414)
- Dimitrios Patoulias
Institutions
- National Institute of Technology Karnataka (IN)
- Manipal Academy of Higher Education (IN)
- Aristotle University of Thessaloniki (GR)
- Kasturba Medical College Hospital (IN)
- Manipal University College Malaysia (MY)
- Ras al-Khaimah Medical and Health Sciences University (AE)
- University of Palermo (IT)
Publication Details
- Journal
- Current Pharmaceutical Design
- Published
- 2025-05-07
- DOI
- https://doi.org/10.2174/0113816128366802250413160625
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.39