Inhibition of Canonical Wnt Signaling in Renal Cell Carcinoma Bone Metastasis: An Immunohistochemical Analysis of DKK1 and LRP5 Expression
A "rebound" pattern of DKK1 expression in bone metastasis lesions and the decreasing LRP5 expression in primary lesions of RCC-BM patients suggested that Wnt/β-catenin signaling was inhibited in RCC-BM. The overexpression of DKK1 and reduced expression of LRP5 suggest that these markers may be useful for the early prediction of RCC-BM.
Authors
- Zixiong Huang (ORCID: https://orcid.org/0000-0003-1602-6830)
- Huaqi Yin (ORCID: https://orcid.org/0000-0001-7253-2549)
- Gongwei Wang (ORCID: https://orcid.org/0000-0002-3248-1270)
- Yiqing Du (ORCID: https://orcid.org/0000-0002-5089-727X)
- Tao Xu (ORCID: https://orcid.org/0000-0001-9359-3164)
Institutions
- Peking University (CN)
- Zhengzhou University (CN)
- Michigan Medicine (US)
- Peking University People's Hospital (CN)
- Henan Cancer Hospital (CN)
Publication Details
- Journal
- Protein and Peptide Letters
- Published
- 2025-05-08
- DOI
- https://doi.org/10.2174/0109298665357331250416081850
- Citations
- 4
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 3.22