Naringenin Targets PI3K p85alpha to Suppress PI3K/AKT Signaling Pathway and Ameliorate Disordered MMP-9 Secretion in Cigarette Smoke Extract-Induced Alveolar Macrophages In Vitro
Our findings revealed that naringenin, a potential candidate for treating smoking-induced lung injury, directly targeted PI3K p85alpha, inhibiting PI3K activity and MMP-9 expression in CSE-induced alveolar macrophages via suppressing the PI3K/AKT signaling pathway.
Authors
- Hao Wu (ORCID: https://orcid.org/0000-0003-1267-8786)
- Xiao Wu (ORCID: https://orcid.org/0000-0003-2470-8743)
- Peibo Li (ORCID: https://orcid.org/0000-0002-2163-2045)
- Weiyang Fan (ORCID: https://orcid.org/0009-0002-1297-6097)
- Pan Chen (ORCID: https://orcid.org/0000-0002-0339-3298)
- Mengli Zhong
- Zhen Chen (ORCID: https://orcid.org/0000-0001-8328-806X)
- Weiwei Su (ORCID: https://orcid.org/0000-0003-2675-1550)
- Ziyan Xu
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Cells
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3390/cells14100678
- Citations
- 1
- Primary Topic
- Protease and Inhibitor Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province