Hard–Soft Dual-State Coatings Regulate Degradation Rate and Biocompatibility of Orthopedic Magnesium Implants
The biomechanical similarity of magnesium to cortical bone, along with its biocompatibility and biodegradability, makes it promising for orthopedic implants. However, rapid degradation compromises the structural integrity and fixation, causing failure. To address this issue, we developed a hard-soft dual-state coating to regulate degradation and improve performance. A dense magnesium hydroxide hard coating was formed by sodium hydroxide treatment, and the hydrogel soft coating formed by freeze-drying was 44.5 μm thick. The dual coating significantly improved the corrosion resistance and mechanical properties. Mg-OH-Hy implants exhibited a reduced corrosion rate of 0.61 mm/year (±0.02), an ultimate fracture force of 750 N (±10), and a pullout force of 350 N (±10). Electrochemical testing revealed an <i>E</i><sub>corr</sub> of -1.08 V and an <i>I</i><sub>corr</sub> of 10<sup>-3·8</sup> mA/cm<sup>2</sup>. This dual coating approach improves mechanical stability, controls degradation, and promotes bone integration, providing personalized solutions for diverse clinical applications.
Authors
- Yabin Zhu (ORCID: https://orcid.org/0000-0002-9610-8707)
- Yujiong Chen (ORCID: https://orcid.org/0000-0002-2696-8875)
- Xiao Hu (ORCID: https://orcid.org/0000-0003-1128-4099)
- Chunhai Ke (ORCID: https://orcid.org/0009-0000-5980-1492)
- Mingming Hao (ORCID: https://orcid.org/0009-0004-2396-8935)
- Jiaqi Zhong (ORCID: https://orcid.org/0000-0002-1976-978X)
- Jianping Chen (ORCID: https://orcid.org/0000-0003-1644-1444)
- Jingyun Ma (ORCID: https://orcid.org/0009-0004-1827-0372)
- Yu Han (ORCID: https://orcid.org/0000-0003-0677-1669)
- Jiangfang Lian (ORCID: https://orcid.org/0009-0002-5038-2775)
- Zhewei Zhang (ORCID: https://orcid.org/0000-0002-1431-2297)
- Botao Liu (ORCID: https://orcid.org/0000-0001-9305-8380)
- Zhaoxiang Peng (ORCID: https://orcid.org/0000-0001-6508-4100)
Institutions
- Ningbo University (CN)
- Chinese Academy of Sciences (CN)
- Suzhou Institute of Nano-tech and Nano-bionics (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
Publication Details
- Journal
- ACS Biomaterials Science & Engineering
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1021/acsbiomaterials.4c01769
- Primary Topic
- Magnesium Alloys: Properties and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Zhejiang Province
- Natural Science Foundation of Ningbo
- Science and Technology Innovation 2025 Major Project of Ningbo
- Natural Science Foundation of Zhejiang Province