Preparation, Optimization, and Characterization of Transdermal Patches Containing Aqueous Extract of Cissus quadrangularis and Ginger officinalis

Background: In Chhattisgarh, Cissus quadrangularis (Family: Vitaceae) and Ginger officinalis (Family: Zingiberaceae) are frequently used as cooking items and in the native healthcare system for the treatment of a variety of diseases. Plants are a great option when it comes to identifying novel products with therapeutic value for drug development. Objectives: The current study was to prepare and assess transdermal patches containing extracts of Harbhanga (Cissus quadrangularis) and Ginger officinalis. The aqueous method was used to produce Cissus quadrangularis and ginger officinalis extracts. Methods: Utilising various concentrations of polyvinylpyrrolidone, the transdermal patch was created with the solvent evaporation method. Diethyl phthalate was utilised to increase penetration and act as a plasticizer. Antibacterial activity was evaluated using the agar well diffusion method. Results: Both extracts were rich sources of calcium, carotene, glycoside, and alkaloids and can be used as a nutritional food. Transdermal patch (T-9) showed good characteristics, such as moisture uptake, folding endurance, and pH. Hence, this formulation was chosen to determine drug content, in vitro drug release, and antimicrobial activity. The patch ranged in thickness from 1.025 + 0.214 to 1.201 + 0.214. The weight homogeneity was good and within range, and the folding endurance was discovered to be consistent. Antimicrobial activity was evaluated using the agar plate method with gram-positive and gram-negative strains. Conclusion: The results showed that the transdermal patch prepared with well-diffusion and the pour-plate technique was the best for the TP-9 transdermal patch. The evaluations used physiochemical parameters, such as moisture content, thickness, weight consistency, and physical appearance.