The Effect of Cinnamon Bark Extract (Cinnamomum burmannii) on Blood Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) Levels in Hyperglycemic Rats

Diabetes mellitus is a metabolic disease with hyperglycemia characteristics due to abnormalities in insulin secretion. Hyperglycemia conditions in diabetics can cause increased production of Reactive Oxygen Species or excessive free radicals and will trigger oxidative stress. One organ that has a risk due to hyperglycemia, for example, is liver damage. Cinnamon bark plant (Cinnamomum burmannii) is one of the plants that contain antidiabetics and antioxidants. The purpose of this study was to determine the effect of cinnamon bark extract on AST and ALT levels in hyperglycemic rats. This study is an experimental study with the design of The Post Test – Only Control Group using 30 rats divided into five groups, namely negative control group (K-), positive control group (K+), treatment group 1 (Dose 100 mg/kgBW), treatment 2 (Dose 200 mg/kg BW) and treatment 3 (Dose 300 mg/kgBW) then continued administration of cinnamon bark extract (Cinnamomum burmannii) for 30 days. Examination of AST and ALT levels is measured using an enzymatic kinetic method spectrophotometer. Data were analyzed with One-Way ANOVA and Post-Hoc Bonferroni. The results showed that cinnamon extract can reduce AST, ALT, and blood glucose levels at low doses of 100 mg/kgBW as evidenced by a P value of < 0.05 meaning that cinnamon extract (Cinnamomum burmannii) can reduce AST and ALT levels in hyperglycemic rats. Keywords: Hyperglycemia, Cinnamon Bark Extract, AST, ALT.