Recurrent MDM2 Amplification in the Spectrum of HMGA2-Altered Pleomorphic Adenoma, Atypical Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma
Immunohistochemical MDM2 expression, including MDM2 amplification, is enriched in the group of HMGA2-altered pleomorphic adenoma, and potentially plays role in malignant progression. This study highlights the importance of recognizing the molecular sub-group of HMGA2-altered pleomorphic adenomas and integrate MDM2 analysis into routine diagnostics to corroborate the cytonuclear atypia in these challenging cases.
Authors
- Niels J. Rupp (ORCID: https://orcid.org/0000-0002-7043-3456)
- Sjors A. Koppes (ORCID: https://orcid.org/0000-0002-8833-531X)
- Tom van Wezel (ORCID: https://orcid.org/0000-0001-5773-7730)
- Ronald van Eijk (ORCID: https://orcid.org/0000-0001-7955-6295)
- Marc Lucas Ooft
- Anne‐Marie Cleton-Jansen (ORCID: https://orcid.org/0000-0002-9048-4867)
- Sylvia L. van Egmond (ORCID: https://orcid.org/0000-0003-2394-5982)
- Dianne J. Terlouw (ORCID: https://orcid.org/0000-0001-5327-8995)
- G. Mihaela Raicu
- Hans Marten Hazelbag (ORCID: https://orcid.org/0009-0003-2182-6952)
- Gerben Eise Breimer (ORCID: https://orcid.org/0000-0003-0365-3667)
- Vincent T.H.B.M. Smit (ORCID: https://orcid.org/0000-0003-3730-5652)
- Daniëlle Cohen (ORCID: https://orcid.org/0000-0002-8694-3522)
- Kimberly S T Burghout
Institutions
- University of Zurich (CH)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Medisch Centrum Haaglanden (NL)
- University Hospital of Zurich (CH)
- St. Antonius Ziekenhuis (NL)
- Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL)
- Rijnstate Hospital (NL)
Publication Details
- Journal
- Head and Neck Pathology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1007/s12105-025-01794-y
- Primary Topic
- Salivary Gland Tumors Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00