Correction of mPTP Dysfunction by some Polyphenol extracts

Annotation: In this article studied the corrective effect of polyphenol extracts PF-1, isolated from the Karelinia caspia plant and PF-4, isolated from the leaf of quince (Cydonia oblonga), growing in the Republic of Uzbekistan, on the permeability of mPTP in the liver of rats was studied. Studies have shown that polyphenol extracts PF-1 and PF-4(1μg/ml, 5μg/ml, 10μg/ml, 15μg/ml) induce mitochondrial mPTP in the presence of Ca2+ ions. The mPTP inhibitory activities of PF-1 and PF-4 polyphenol extracts ranged from 30% to <83%. The results obtained make it possible to create membrane-active drugs based on extracts of polyphenols PF-1 and PF-4.