A Plasma Metabolic Signature to Diagnose Pulmonary Tuberculosis and Monitor Treatment Response
The plasma Kyn/Trp ratio and retinol represents a promising metabolic signature that could advance TB diagnostics.
Authors
- Laura Donnelly
- Lisa Elon (ORCID: https://orcid.org/0000-0003-2307-6617)
- Azhar Nizam (ORCID: https://orcid.org/0000-0001-9995-5920)
- Matthew James Magee (ORCID: https://orcid.org/0000-0002-8068-5796)
- Bezalam Tesfaye
- Jeffrey Michael Collins (ORCID: https://orcid.org/0000-0002-6574-0873)
- Thomas R. Ziegler (ORCID: https://orcid.org/0000-0001-9329-1481)
- Mary M. Nellis
- Sara C. Auld (ORCID: https://orcid.org/0000-0002-8972-3736)
- Rebecca F. Goldstein (ORCID: https://orcid.org/0000-0002-9215-8459)
- Melanie Quezada (ORCID: https://orcid.org/0000-0002-2057-3477)
- Azeb Tarekegn
- Loren E. Sasser (ORCID: https://orcid.org/0000-0003-3348-9933)
- Shunsuke Sakai
- Paul Ogongo (ORCID: https://orcid.org/0000-0002-0093-5768)
- Nahom Getachew
- Tawania Fergus
- Nazir Ismail (ORCID: https://orcid.org/0000-0001-7696-3776)
- Nestani Tukvadze (ORCID: https://orcid.org/0000-0002-0276-1204)
- Lisa Sharling (ORCID: https://orcid.org/0000-0001-6720-0136)
- Cheryl L. Day
- Samuel Bayu
- Meghan Franczek
- Andrea Knežević (ORCID: https://orcid.org/0000-0002-0741-2150)
- Wendy Whatney
- Dean P. Jones (ORCID: https://orcid.org/0000-0002-2090-0677)
- Anirudh Rao (ORCID: https://orcid.org/0000-0002-3202-2832)
- Seegar Swanson (ORCID: https://orcid.org/0009-0004-0265-8348)
- Russell Ryan Kempker (ORCID: https://orcid.org/0000-0002-7188-4996)
- Salim Allana (ORCID: https://orcid.org/0000-0002-0643-143X)
- Max S. Y. Lau (ORCID: https://orcid.org/0000-0001-6590-0294)
- Shirin Jabbarzadeh (ORCID: https://orcid.org/0009-0008-2096-2430)
- Daniel L. Barber (ORCID: https://orcid.org/0000-0001-7008-7509)
- Devin Columbus
- Jenna Daniel
- N. Sarita Shah
- Daniel Mussa
- Melat Gebre-Medhin
- Liya Wassie (ORCID: https://orcid.org/0000-0002-5494-5275)
- Lance Allyn Waller (ORCID: https://orcid.org/0000-0001-5002-8886)
- Yonas Abebe (ORCID: https://orcid.org/0000-0002-1127-1805)
- Jemal Hussein
- Abraham Aseffa (ORCID: https://orcid.org/0000-0002-8028-1150)
- Dawn L. Comeau (ORCID: https://orcid.org/0000-0003-2877-9151)
- Susan M. Ray (ORCID: https://orcid.org/0000-0002-6327-088X)
- Keith D. Kauffman (ORCID: https://orcid.org/0000-0001-7208-1565)
- Jyothi Rengarajan (ORCID: https://orcid.org/0000-0003-1241-4705)
- Henry M. Blumberg (ORCID: https://orcid.org/0000-0002-3110-2443)
- Nandakumar S. Narayanan (ORCID: https://orcid.org/0000-0002-0427-0003)
- Hao Wu (ORCID: https://orcid.org/0000-0003-1269-7354)
- Alemayehu Geletu
- Angela Campbell (ORCID: https://orcid.org/0000-0003-3990-3656)
- Alemayehu Kifle
- Kidist Bobosha (ORCID: https://orcid.org/0000-0001-8091-7182)
- Selam Jemberu
- Mitin Wendaferew
- Zenebech Assefa
- Selam Dechasa
- Firaol Wagari
- Firaol Degaga
- Rediet Zerihun
- Mekdelawit Wondiyfraw
- Meaza Zewdu
- Ruth Mekonnen
- Fisseha Mulate
- Eleni Zeleke
- Dawit Tayachew Bere
- Million Legesse
- Yunyun Chen (ORCID: https://orcid.org/0000-0002-3681-7739)
- J. Ernst (ORCID: https://orcid.org/0000-0001-9951-6207)
- Anthony Tran (ORCID: https://orcid.org/0000-0002-5570-6436)
- Neel Gandhi (ORCID: https://orcid.org/0000-0003-1758-1764)
- Tsegaye Hailu
- James C.M. Brust
- Sebsibe Neway
- Edom Girma
- Mahlet Mekuria
- Gebeyehu Assefa
- Medina Hamza
- H Solomon
- Daniel Getachew
- Ranjna Madan Lala
- Zewdu Solomon
- Misker Kedir
- Emebet Haile
- Daniel Degefu
- Bezawit Dinberu
- Gutema Jebe
Institutions
- National Institutes of Health (US)
- Albert Einstein College of Medicine (US)
- Emory University (US)
- Swiss Tropical and Public Health Institute (CH)
- University of California, San Francisco (US)
- University of the Witwatersrand (ZA)
- National Center for Tuberculosis and Lung Disease (GE)
- National Institute of Allergy and Infectious Diseases (US)
- Armauer Hansen Research Institute (ET)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1093/infdis/jiaf240
- Citations
- 6
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 8.38