Development and application of a whole transcriptome sequencing assay for the detection of gene fusions in clinical cancer specimens
We have developed a novel WTS assay with high sensitivity, specificity, repeatability and reproducibility. This assay can identify potentially actionable gene fusions and provides valuable insights into the fusion landscape in various cancers, which may help guide treatment decisions and aid in diagnosis and prognosis.
Authors
- Caicun Zhou (ORCID: https://orcid.org/0000-0002-6958-0766)
- Xinxin Tan
- Jing Bai (ORCID: https://orcid.org/0009-0003-9650-3023)
- Xuefeng Xia (ORCID: https://orcid.org/0000-0002-4419-1158)
- Lingwei Yang (ORCID: https://orcid.org/0000-0001-6449-9937)
- Xuefei Li (ORCID: https://orcid.org/0000-0003-0188-5667)
- Xinhua Du
- Jiaxin Ma (ORCID: https://orcid.org/0000-0001-9812-0999)
- Songchen Zhao (ORCID: https://orcid.org/0000-0002-3238-311X)
- Haihui Sheng (ORCID: https://orcid.org/0000-0003-1350-3769)
- Meng Lu (ORCID: https://orcid.org/0000-0002-7030-9623)
- Xiaorui Fu (ORCID: https://orcid.org/0000-0003-4778-2284)
- Xin Yi (ORCID: https://orcid.org/0000-0003-2988-1588)
- Yanfang Guan (ORCID: https://orcid.org/0000-0002-6722-2615)
- Yuting Yi (ORCID: https://orcid.org/0000-0003-2125-9073)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-4835-8541)
Institutions
- Tongji University (CN)
- Peking University (CN)
- Shanghai Pulmonary Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1186/s12885-025-14186-w
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Shanghai Pulmonary Hospital