Difluoromethylation of N-Pyrazole Using 1-Chloro-1, 1-Difluoromethane Under Mild Condition

ABSTRACT: A simple and efficient protocol for the direct Difluoromethylation of pyrazoles has been developed. The reaction makes use of commercially available and easy handling ClCHF2 as difluoromethyl source, and provides a cost-efficient and environmentally benign access to some difluoromethylated biologically relevant molecules. Keywords: Difluoromethylation Commercially feasible route, Spectral Analysis, Pyrazoles

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Publication Details

Journal
INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT
Published
2025-05-08
DOI
https://doi.org/10.55041/ijsrem47290
Primary Topic
Fluorine in Organic Chemistry
Type
article
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article

Difluoromethylation of N-Pyrazole Using 1-Chloro-1, 1-Difluoromethane Under Mild Condition

D Tushar
INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT
Fluorine in Organic Chemistry
article

Difluoromethylation of N-Pyrazole Using 1-Chloro-1, 1-Difluoromethane Under Mild Condition

D Tushar
article en

Abstract

ABSTRACT: A simple and efficient protocol for the direct Difluoromethylation of pyrazoles has been developed. The reaction makes use of commercially available and easy handling ClCHF2 as difluoromethyl source, and provides a cost-efficient and environmentally benign access to some difluoromethylated biologically relevant molecules. Keywords: Difluoromethylation Commercially feasible route, Spectral Analysis, Pyrazoles

INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENTVol. 09(05)
Openalex Percentile: Top 93%
Fluorine in Organic Chemistry
DOIOpen Access PDFOpenAlex
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Difluoromethylation of N-Pyrazole Using 1-Chloro-1, 1-Difluoromethane Under Mild Condition — D Tushar · INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT (2025) | TGRS Research Map | TGRS