Pericytes in Notch3 knockout and diabetic mice form engorged connections with vascular endothelial cells
As the Notch3 receptor plays an important role in cell signaling between pericytes and endothelial cells, and diabetes is also known to disrupt Notch3 signaling, our hypothesis for the enlarged peg phenotype is that the pericytes and endothelial cells actively increase their contact surface to compensate for loss of Notch3 signaling.
Authors
- Philip Seifert (ORCID: https://orcid.org/0000-0002-6951-7097)
- Michael O’Hare (ORCID: https://orcid.org/0000-0002-2833-3697)
- Joseph F. Arboleda‐Velásquez (ORCID: https://orcid.org/0000-0002-3192-9117)
- Timothy E. Vanderleest (ORCID: https://orcid.org/0000-0003-2929-5378)
- H Gordon (ORCID: https://orcid.org/0009-0005-9561-5706)
Institutions
- Massachusetts Eye and Ear Infirmary (US)
Publication Details
- Journal
- ScienceBank
- Published
- 2025-05-08
- DOI
- https://doi.org/10.61340/pn3k1dm
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Good Ventures Foundation
- National Institutes of Health